Symposium MF01: Advances in Polymer-based Soft Matter for Additive Manufacturing

Shangsi Chen, Zhaohe Xu, and Min Wang, The University of Hong Kong

3D Printed core-shell structured scaffolds with NIR-Triggered dual release for cancer therapy and uterine tissue regeneration

Written by Swati Suman

Gynecologic cancers and uterine fibroids often result in uterus dysfunction and hence result in female infertility. The hydrogel/poly(L-lactide-co-trimethylene carbonate hormone estradiol (E2)-containing polydopamine (PTMC-PDA@E2) coating layer significantly enhanced mechanical properties and strengthened the uterus better than the native tissues. The chronological release of the E2 over a certain period (28 days) promotes uterine tissue regeneration. This novel Gel- anticancer drug doxorubicin hydrochloride (DOX)/PTMC-PDA@E2 core-shell scaffolds have shown their potential for postoperative management in female patients. The coating layer protected the Gel-DOX core from rapid biodegradation and thus inhibited the burst release of DOX.