Plant Health Electronics
Symposium X—Frontiers of Materials Research

Got a Multiple Sclerosis sensor? Kateryna says YES!

The brain controls our actions. It uses nerve cells to instruct and communicate with the rest of the body. If you want to sit, the brain signals your muscles to contract by firing action potential down the nerve fibers. A protective insulating coating surrounds the nerve fibers to preserve the signal fidelity, so your muscles get the right message. But if this protective layer is damaged, the signal sent by the brain could get corrupted, thus potentially disabling your brain and central nervous system. This is what happens in the autoimmune disease called Multiple sclerosis (MS). Autoimmune means that your own body's immune system causes this nerve damage.

An estimated 2.8 million people have MS worldwide. Although there is no cure, diagnosis and monitoring can help manage the symptoms and improve the affected people's lifestyle. So, we need a sensor that can help us do that. Neurofilament light chain (NF-L) is the potential biomarker for MS and other neurological disorders. If we can detect this protein, which is released into the cerebrospinal fluid and blood due to the above nerve damage, we can assess the extent of MS.

Kateryna Solodka from the University of Modena and Reggio Emilia in Italy developed an ultra-sensitive label-free organic transistor-based sensor that can help monitor MS by detecting NF-L.

Kateryna at 2022 MRS Spring Meeting

I can't wait to see it developed as a commercial product, improving the lives of affected people worldwide! Thank you, Kateryna, for such impactful work!

More Info: Detection of Neurofilament Light Chain with Label-Free Electrolyte-Gated Organic Field-Effect Transistors

EQ03.20.01: Label-Free, Sub-Picomolar Detection of Neurofilament Light Chain with Electrolyte-Gated Organic Field-Effect Transistor-Based Biosensors

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