Symposium SM03: Advanced Neural Materials and Devices
Symposium SM03: Advanced Neural Materials and Devices

Symposium SM01: Materials Modulating Stem Cells and Immune Response

Olga Kraevaya, Russian Academy of Sciences

Late News: One-Step Synthesis of Water-Soluble Fullerene Derivative with Myogenic Activity and Pronounced Antiviral Properties

Written by Arun Kumar

This talk presented by Olga Kraevaya from the Russian Academy of Sciences shows the antiviral activity and differentiation activity of water-soluble fullerene derivative (FPA) synthesized from a one-step synthesis process with tris(trimethylsilyl) phosphite and potassium carbonate. Kraevaya says that their method effectively produces fullerene derivative particles at an 85% yield. FPA compound demonstrated pronounced antiviral activity against Feline coronavirus and Influenza A (H3N2) virus with 50% inhibition activity at concentrations of 4.6-4.8 µg/ml. It also showed moderate antiviral activity against other viral pathogens such as Varicella zoster virus, Cytomegalovirus, Cowpox virus, Feline herpes virus, Influenza A (H1N1), Herpes simplex virus (HSV-1, HSV-2), Influenza B virus, and Human immunodeficiency virus (HIV-1, HIV-2) at 50% inhibitory concentrations of 20-49 µg/ml.

Incubation of the FPA fullerene particles with mesenchymal stem cells (MSCs) show changes in the cell morphology and an altered expression of myogenic surface markers that indicate an MSC differentiation into a myogenic lineage. This result markedly shows an unusual MSCs differentiation stimulator activity for water-soluble fullerene derivatives.

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