Koon Gee Neoh, National University of Singapore
Functionalization strategies for antimicrobial coatings: Efficacy, stability and scalability
Written by Mary Nora Dickson
Bacterial biofilm formation on implanted medical devices such as catheters is a devastating problem. Moreover, the bacteria that form biofilm can be harbored on hospital surfaces. Koon Gee Neoh from the National University of Singapore has developed strategies to coat surfaces with antimicrobial materials.
Her innovation was the novel coating strategies: UV or heat-induced graft polymerization, thiol-linking, and crosslinking. Neoh utilizes alginate, an antiadhesive coating to prevent bacteria from sticking onto a medical device. She employs quaternized chitosan as a bactericidal material to kill adherent bacteria on hospital surfaces. In her studies, the surfaces coated with these antibacterial materials were effective and, crucially, durable. Neoh plans to begin testing these surfaces in clinical environments, to reduce patients’ risk of infection during hospital stays.